carbonic anhydrases: battlefield for enzyme inhibitor and activator drugs?
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منابع مشابه
Human Carbonic Anhydrases
Sequence studies of human erythrocyte carbonic anhydrase B show that it contains 256 residues. A series of relatively small peptides soluble in aqueous solutions obtained by chymotryptic and tryptic digestion of the enzyme, large peptides containing only COOH-terminal lysine or arginine as well as those resulting from more limited cleavage of the enzyme, and cyanogen bromide cleavage products s...
متن کاملPolyamines and α-Carbonic Anhydrases.
Natural products represent a straightforward source for molecular structures bearing a vast array of chemical features and potentially useful for biomedical purposes. Recent examples of this type include the discovery of the coumarins and the polyamine natural products as atypical chemotypes for the inhibition of the metalloenzymes carbonic anhydrases (CAs; EC 4.2.2.1). CA enzymes are establish...
متن کاملTransport metabolons with carbonic anhydrases
THE CONCEPT OF THE TRANSPORT METABOLON A metabolon has been defined as a “temporary, structural-functional, supramolecular complex of sequential metabolic enzymes and cellular structural elements, in which metabolites are passed from one active site to another without complete equilibration with the bulk cellular fluids” (Srere, 1985, 1987). This substrate channeling should decrease transit tim...
متن کاملNew fluorescent probes for carbonic anhydrases.
We report the synthesis and fluorescence properties of naphthalenesulfonamide derivatives as active site probes for carbonic anhydrases.
متن کاملStructure and expression of mammalian carbonic anhydrases.
tions make it possible to ascribe specific roles to particular residues, such as the conserved glycine residues 141 at bends in the basic fold which appear to constitute alcohol dchydrogenase per se. Each of these concepts can now be further tested by directed mutagenesis. Regarding the enzymic mechanisms, the basic properties of the zinc dehydrogenases have essentially been known for some time...
متن کاملCarbonic Anhydrases and Their Biotechnological Applications
The carbonic anhydrases (CAs) are mostly zinc-containing metalloenzymes which catalyze the reversible hydration/dehydration of carbon dioxide/bicarbonate. The CAs have been extensively studied because of their broad physiological importance in all kingdoms of life and clinical relevance as drug targets. In particular, human CA isoform II (HCA II) has a catalytic efficiency of 108 M-1 s-1, appro...
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عنوان ژورنال:
journal of paramedical sciencesجلد ۴، شماره ۴، صفحات ۰-۰
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